Diabemin XR Adverse Reactions

As with all medications, metformin can cause adverse drug reactions. The following adverse drug reactions are presented by frequencies which are defined as follows: Very common: Gastrointestinal discomfort such as nausea, vomiting, diarrhea, abdominal pain and loss of appetite may occur especially at the beginning of treatment. These symptoms are generally transient and can be reduced by taking metformin with meals. Should these symptoms continue, patients must stop taking the treatment and consult their doctor.
Common: Taste disturbance.
Very rare: Lactic acidosis is a very serious complication, which results in vomiting, abdominal pain with muscle cramps and/or general feeling of malaise with severe fatigue and which requires specific treatment. If this occurs, patients should stop taking metformin hydrochloride (DIABEMIN XR) immediately and consult their doctor promptly. Lactic acidosis is a medical emergency and must be treated in a hospital.
Skin reactions such as erythema (red skin), itching or urticaria (eruption with itching).
Decreased vitamin B₁₂ levels (to take into consideration if the patient is suffering from megaloblastic anemia).
Isolated cases of liver function test abnormalities or hepatitis resolving upon metformin hydrochloride (DIABEMIN XR) discontinuation.
Any undesirable or distressing effect must be reported to the doctor or pharmacists. If an undesirable effect is severe, occurred suddenly or gets worse rapidly, the doctor must be consulted immediately to prevent serious reactions.